@Article{Whiteside2018,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
year="2018",
title="The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer",
abstract="Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma by size exclusion chromatography can be fractionated into TEX and non-TEX by immune capture on beads. Profiling of molecular and genetic contents of TEX shows that levels if immunosuppressive proteins, such as PD-L1, carried by TEX associate with disease progression. The data suggest that TEX have a to serve as tumor surrogates, while immune cell-derived exosomes might serve as biomarkers of immune dysfunction in cancer.",
author="Whiteside, Theresa L.",
pages="38--40",
doi="10.5114/wo.2018.73882",
url="http://dx.doi.org/10.5114/wo.2018.73882"
}