@Article{Romanowicz-Makowska2005,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="4",
number="3",
year="2005",
title="The role of BRCA1 mutations and G/C polymorphism of RAD51 in breast cancer",
abstract=" Aim:  In present work the frequency of BRCA1 germ-line mutations and the RAD51 G/C polymorphism in patients with breast cancer was investigated.   Methods:  Blood was obtained from 50 breast cancer women. Blood samples age matched healthy individuals (n = 46) served as control. The G/C polymorphism and BRCA1 mutations were determined by PCR-RFLP methods.   Results:  The distribution of the genotypes of the G/C polymorphism RAD51 in both control and patients did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences in the genotype distributions and allele frequencies between node-positive and node-negative patients. In present study one Ex20insC mutations of BRCA1 gene was identified in women with breast cancer.   Conclusion:  Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer. The lack of detectable BRCA1 germ-line mutations in most cases suggests that there are probably additional, as yet unidentified genes predisposing to this disease.",
author="Romanowicz-Makowska, Hanna
and Sobczuk, Anna
and Smolarz, Beata
and Zadrożny, Marek
and Westfal, Bogusław
and Stetkiewicz, Tomasz
and Kulig, Andrzej",
pages="10--14",
url="https://www.termedia.pl/The-role-of-BRCA1-mutations-and-G-C-polymorphism-of-RAD51-in-breast-cancer,4,3377,1,1.html"
}