@Article{Żaworonek2018,
journal="Klinika Oczna / Acta Ophthalmologica Polonica",
issn="0023-2157",
volume="120",
number="2",
year="2018",
title="The role of integrins in eye diseases",
abstract="Integrins belong to the cell adhesion molecules. Integrins and their ligands play the main role in physiological and pathological processes: cell migration, cell differentiation, hemostasis, adhesion, angiogenesis and wound healing. The main task of integrin is to facilitate biochemical and mechanical signal transmission across the plasma membrane in a bidirectional manner. The sig­nals trigger integrin transformation from an inactive form into a ligand-binding state. Integrins play an important role in physiological (embryogenesis, tissue growth and development) and pathological (allergy, inflammation, cancer) processes, being particularly involved in dry eye disease, age-related macular degeneration and diabetic macular edema. Improved understanding of integrins can contribute to the development of new diagnostic methods and advances in immunotherapy.",
author="Żaworonek, Justyna
and Żelazowska-Rutkowska, Beata
and Bryl, Anna
and Mrugacz, Małgorzata
and Cylwik, Bogdan",
pages="113--116",
doi="10.5114/ko.2018.79132",
url="http://dx.doi.org/10.5114/ko.2018.79132"
}