@Article{Kapelusiak-Pielok2005,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="43",
number="2",
year="2005",
title="Original articleThe protective action of alpha-tocopherol on the white matter lipids during moderate hypoxia in rats",
abstract="Hypoxia and ischemia acting on the brain cause alterations of the level of lipids and sterols.  Famile 3.0-3.5-month-old rats were used for the experiment. They were given alpha-tocopherol in the dose of 11.43 mg/kg of body weight through seven days, then underwent hypoxia (7% of oxygen in the breathing mixture) and myelin was isolated in four times after experiment: 4, 24 hours, 14 days and 2 months after experiment.  Three lipids groups were isolated that are neutral lipids, galactolipids and phospholipids. They were quantitatively analyzed with spectrophotocolorimetry. The obtained results indicate that vitamin E administration to animals does not cause significant changes of brain lipids levels. However, alpha-tocopherol administred before moderate hypoxia balances the concentrations of lisophosphatidylcholine and phosphatidylinositide and cerebrosides with control level 2 months after experiment. Vitamin E changes in concentration of the myelin neutral lipids.  Vitamin E administered before experimental moderate hypoxia stabilizes some membrane lipids and could be used in brain hypoxia.",
author="Kapelusiak-Pielok, Magdalena
and Adamczewska-Goncerzewicz, Zofia
and Dorszewska, Jolanta
and Grochowalska, Alina",
pages="103--108",
url="https://www.termedia.pl/Original-article-The-protective-action-of-alpha-tocopherol-on-the-white-matter-lipids-during-moderate-hypoxia-in-rats,20,3432,1,1.html"
}