@Article{Chwalba2015,
journal="Pediatric Endocrinology Diabetes and Metabolism",
issn="2081-237X",
volume="21",
number="4",
year="2015",
title="Role of gluten-free diet in pathogenesis of type 1 diabetes – what new?",
abstract="Over the last decades, the association between coeliac disease and other autoimmune disorders, such as autoimmune thyroid diseases or diabetes mellitus type 1 has been well established through many studies, and to this day is subject to an on-going clinical and scientific investigation worldwide. Type 1 diabetes (T1D) and coeliac disease (CD) share a similar genetic background, with high susceptibility associated with the HLA-DQ2/DQ8 genotype. Interplay between ingested gluten and the subsequent development of type 1 diabetes has been revealed by studies in humans and animals. The study shows that a diet without gluten reduces the level of NKG2D receptor and its ligand expression in mice on a gluten-free (GF) diets. Thus, gluten may affect diabetes development by influencing proportional changes in immune cell populations or by modifying the cytokine/chemokine pattern towards an inflammatory profile. This supports an important role for gluten intake in the pathogenesis of type 1 diabetes. It is reasonable to conduct further researchto clarify whether a gluten-free dietcould prevent disease in susceptible individuals or be used with newly diagnosed patients to stop the disease. These observations may be important for the primary prevention of diabetes.",
author="Chwalba, Artur
and Otto-Buczkowska, Ewa",
url="https://www.termedia.pl/-Rola-diety-bezglutenowej-w-patogenezie-cukrzycy-typu-1-co-nowego-,138,36582,1,1.html"
}