@Article{Leońska-Duniec2019,
journal="Biology of Sport",
issn="0860-021X",
volume="36",
number="3",
year="2019",
title="Association of the TNF-α -308G/A polymorphism with lipid profile
changes in response to aerobic training program",
abstract="Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesityrelated traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that carriers of the GG genotype are associated with decreases in post-training high-density lipoprotein cholesterol (HDL-C) levels (p<0.001). Additionally, we revealed that participants with the GG genotype had a higher low-density lipoprotein cholesterol (LDL-C) level (p=0.046) during the entire study period. It could be concluded that harboring the GG genotype of rs1800629 may be considered to be a disadvantageous factor in the context of training-induced effects on lipid profile changes in young female participants.",
author="Leońska-Duniec, Agata
and Ficek, Krzysztof
and Świtała, Katarzyna
and Cięszczyk, Paweł",
pages="291--296",
doi="10.5114/biolsport.2019.85456",
url="http://dx.doi.org/10.5114/biolsport.2019.85456"
}