@Article{Biernacka2005,
journal="Archives of Medical Science",
issn="1734-1922",
volume="1",
number="2",
year="2005",
title="Short communicationInterleukin-6 serum concentration in patients with impaired growth hormone secretion",
abstract="There is a growing number of studies which have revealed that the growth hormone (GH) plays a role in regulation of systemic inflammatory response. Interleukin-6 (IL-6) is a well established pro-inflammatory, proangiogenic and adipocyte expressed cytokine that is also involved in pituitary tumors pathophysiology.  In this study, using commercially available kits, we aimed to determine serum concentrations of  IL-6, GH and IGF-1 in the following groups of age and sex matched patients expressing impaired growth hormone secretion: patients with active acromegaly (n=11), patients cured from acromegaly (n=14), patients exhibiting growth hormone deficiency (GHD) induced by pituitary tumors (n=12), patients with GHD unrelated to pituitary tumors (n=10) and control group of healthy volunteers (n=15).  Concentrations of IL-6 were significantly higher in both GHD groups with reference to controls. Acromegalic patients revealed comparable to healthy subjects IL-6 concentrations. Using segmental regression applied to the group combined of all patients (n=62), a cut off point for GH=2.27 ng/ml was determined below which a negative correlation with IL-6 was confirmed (r=-0.56, p<0.048). Multiple regression failed to reveal any correlation between IL-6 and IGF-1/BMI in groups of patients irrespective of the GH concentration threshold. Taken together, we conclude that GHD in adults is accompanied by increased serum concentrations of IL-6. Nevertheless, neither adipocytes nor pituitary adenoma cells are the major source of IL-6 in these patients.  Lack of correlation of IL-6 with IGF-1 suggests the direct impact of low GH concentrations in IL-6 induction. Noteworthy, increased IL-6 concentrations can be secondary to the atherosclerotic process augmented by GHD via mechanisms which require further investigations.",
author="Biernacka, Anna
and Dobaczewski, Marcin
and Ławnicka, Hanna
and Kunert-Radek, Jolanta",
pages="123--125",
url="https://www.termedia.pl/Short-communication-Interleukin-6-serum-concentration-in-patients-with-impaired-growth-hormone-secretion,19,3733,1,1.html"
}