@Article{Suzuki2019,
journal="Journal of Contemporary Brachytherapy",
issn="1689-832X",
volume="11",
number="5",
year="2019",
title="Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report",
abstract="Radiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiation with immunotherapy. However, nearly all pre-clinical and clinical studies evaluating a combination of radiation and immunotherapies have used external beam radiation therapy. We present in this case report, the abscopal effect observed in a 30-year-old Japanese woman with metastatic renal cell carcinoma after the treatment with high-dose-rate interstitial brachytherapy combined with nivolumab. This is the first published report demonstrating an abscopal effect following brachytherapy for human malignancy. Our case indicates that immuno-oncology effects are not limited to external beam irradiation regimens as they can also be attained by brachytherapy.",
author="Suzuki, Gen
and Masui, Koji
and Yamazaki, Hideya
and Takenaka, Tadashi
and Asai, Syunsuke
and Taniguchi, Hidefumi
and Nakamura, Terukazu
and Ukimura, Osamu
and Yamada, Kei",
pages="458--461",
doi="10.5114/jcb.2019.89365",
url="http://dx.doi.org/10.5114/jcb.2019.89365"
}