@Article{Gałęcki2019,
journal="Pediatria Polska - Polish Journal of Paediatrics",
issn="0031-3939",
volume="94",
number="5",
year="2019",
title="Paediatric immunoglobulin A deficiency revisited",
abstract="Immunoglobulin A (IgA) is the most abundant antibody isotype on mucosal surfaces, with predominantly neutralising non-activating functions, and which plays multifaceted roles in the immune system. IgA protects the host from pathogen invasion in the gastrointestinal and respiratory tracts, enhances diversification of microbiota, and maintains the intestinal homeostasis, exerting its twofold proinflammatory and anti-inflammatory functions by different immune cells and receptors. Therefore, IgA deficiency in children encompasses a broad spectrum of clinical phenotypes including infectious, allergic, autoimmune, and inflammatory conditions. In this review we also provide new insight into the genetic background and immunopathology of IgA deficiency in children.",
author="Gałęcki, Viktor
and Janas, Michał
and Juzyk, Piotr
and Oronowicz, Radosław
and Soloch, Martyna
and Starczewski, Wojciech
and Weigt, Agata
and Szczawińska-Popłonyk, Aleksandra",
pages="311--318",
doi="10.5114/polp.2019.89497",
url="http://dx.doi.org/10.5114/polp.2019.89497"
}