@Article{Nowak2019,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="106",
number="5",
year="2019",
title="Early diagnosis of porphyria cutanea tarda as a key to avoiding scarring – a mild form of the disease",
abstract="Porphyria cutanea tarda belongs to the group of porphyrias. Porphyria is a heme disorder caused by an acquired or congenital defect of hepatic enzymes. This consequently leads to the accumulation of porphyrins in various organs. In porphyria cutanea tarda, there is a deficiency of the enzyme uroporphyrinogen decarboxylase. The most frequent factor that leads to damage of this enzyme is drug- or alcohol-induced liver insufficiency. In porphyria cutanea tarda typical clinical manifestations include blisters, erosions, crusts, and milia, that arise predominantly in sun-exposed areas. Furthermore, the skin becomes atrophic, susceptible to injuries and scarring. In our patient, the skin chances were induced by estrogen treatment of endometriosis in combination with UV-exposure. In this case the diagnosisi was established early and significant clinical consequences could be avoided.",
author="Nowak, Marcela
and Mehrholz, Dorota
and Barańska-Rybak, Wioletta
and Nowicki, Roman",
pages="515--521",
doi="10.5114/dr.2019.89999",
url="http://dx.doi.org/10.5114/dr.2019.89999"
}