@Article{Klimiuk2005,
journal="Reumatologia/Rheumatology",
issn="0034-6233",
volume="43",
number="5",
year="2005",
title="ORIGINAL PAPER The value of the assessment of interleukin-6 (IL-6), matrix metalloproteinases and their inhibitors in serum in the assessment of rheumatoid arthritis activity",
abstract="The aim of the study was to explore whether the serum level of interleukin 6 (IL-6) is correlated with matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), and with clinical markers of the disease activity in rheumatoid arthritis (RA). Concentrations of IL-6, interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), gelatinase B (MMP-9), TIMP-1 and TIMP-2 were measured with an ELISA technique in serum of 32 RA patients. We found the correlations between IL-6 and total measured MMPs (p<0.001), and total measured TIMPs (p<0.001). Furthermore, serum IL-6, MMPs and TIMPs correlated with the erythrocyte sedimentation rate, C reactive protein level, the number of tender and swollen joints, and Ritchie articular index (RAI). We conclude that analysis of the serum IL-6, MMPs and TIMPs levels may be useful in the assessment of the RA activity.",
author="Klimiuk, Piotr Adrian
and Sierakowski, Stanisław
and Gińdzieńska-Sieśkiewicz, Ewa
and Chwiećko, Justyna",
pages="239--242",
url="https://www.termedia.pl/ORIGINAL-PAPER-The-value-of-the-assessment-of-interleukin-6-IL-6-matrix-metalloproteinases-and-their-inhibitors-in-serum-in-the-assessment-of-rheumatoid-arthritis-activity,18,3887,1,1.html"
}