@Article{Samotij2020,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="37",
number="2",
year="2020",
title="Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances",
abstract="Psoriasis is a common, chronic, inflammatory, immune-mediated skin disease affecting about 2% of the world’s population. According to current knowledge, psoriasis is a complex disease that involves various genes and environmental factors, such as stress, injuries, infections and certain medications. The chronic inflammation of psoriasis lesions develops upon epidermal infiltration, activation, and expansion of type 1 and type 17 Th cells. Despite the enormous progress in understanding the mechanisms that cause psoriasis, the target cells and antigens that drive pathogenic T cell responses in psoriatic lesions are still unproven and the autoimmune basis of psoriasis still remains hypothetical. However, since the identification of the Th17 cell subset, the IL-23/Th17 immune axis has been considered a key driver of psoriatic inflammation, which has led to the development of biologic agents that target crucial elements of this pathway. Here we present the current understanding of various aspects in psoriasis pathogenesis.",
author="Samotij, Dominik
and Nedoszytko, Bogusław
and Bartosińska, Joanna
and Batycka-Baran, Aleksandra
and Czajkowski, Rafał
and Dobrucki, Iwona
and Dobrucki, Lawrence
and Górecka-Sokołowska, Magdalena
and Janaszak-Jasienicka, Anna
and Krasowska, Dorota
and Kalinowski, Leszek
and Macieja-Stawczyk, Marta
and Nowicki, Roman
and Owczarczyk-Saczonek, Agnieszka
and Płoska, Agata
and Purzycka-Bohdan, Dorota
and Radulska, Adrianna
and Reszka, Edyta
and Siekierzycka, Anna
and Słomiński, Andrzej
and Słomiński, Radomir
and Sobalska-Kwapis, Marta
and Strapagiel, Dominik
and Szczerkowska-Dobosz, Aneta
and Szczęch, Justyna
and Żmijewski, Michał
and Reich, Adam",
pages="135--153",
doi="10.5114/ada.2020.94832",
url="http://dx.doi.org/10.5114/ada.2020.94832"
}