@Article{Okoń2020,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="71",
number="1",
year="2020",
title="Image analysis discloses differences in nuclear parameters between ERG+ and ERG– prostatic carcinomas",
abstract="Prostatic carcinoma (PC) is the most frequent urologic cancer and one of the most frequent cancers in males; it is a heterogeneous disease, in terms of molecular features, morphology and prognosis. About half of cases depends on TMPRSS2-ETS translocation which leads to a production of ERG transcription factor. ERG+ and ERG– cancers seem to differ in a number of features, which could lead to an altered nuclear structure; the aim of the study was to test this hypothesis. The material consisted of total 39 PC cases, representing ERG+ and ERG–, as well as Gleason pattern 3 and 4. Filtering by color deconvolution and automatic segmentation were used, and the properly detected nuclei were manually selected. From each case fifty nuclei were obtained; then geometric features and texture parameters were assessed. The analysis of the collected data showed differences both between ERG+/ERG– and Gleason pattern 3 and 4 cases in most of the features analyzed. Our results suggest that indeed the ERG status, thus likely TMPRSS2-ETS translocation, has an impact on morphology of nuclei in PC, and their differences are evident enough to be detectable by image analysis.",
author="Okoń, Krzysztof
and Dyduch, Grzegorz
and Białas, Magdalena B.
and Milian-Ciesielska, Katarzyna
and Szpor, Joanna
and Leszczyńska, Iga
and Tyrak, Katarzyna
and Szopiński, Tomasz
and Chłosta, Piotr",
pages="20--29",
doi="10.5114/pjp.2020.95412",
url="http://dx.doi.org/10.5114/pjp.2020.95412"
}