@Article{Terzi2020,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="71",
number="2",
year="2020",
title="C-KIT mutation in thymic carcinomas",
abstract="Thymic epithelial tumours are rare malignancies of the anterior superior mediastinum. Several studies have analysed the presence of c-KIT mutations in thymic carcinoma. Immunohistochemical c-KIT expression and mutations in exons 8, 9, 11, 13, 14, 17, and 18 of the KIT gene and in the promoter region of the TERT gene (chr5, 1,295,228C>T/A and 1,295,250C>T) were analysed by PCR based direct sequencing using representative formalin-fixed paraffin-embedded tumour samples of 18 thymic carcinomas. Of 18 patients, 4 test samples were excluded from the study due to inadequate DNA quality. Of 14 patients with thymic carcinomas, KIT and TERT mutation was not detected in any samples. C-KIT expression was associated with nearly a worse overall survival (median time 24.160-49.840, log-rank, p = 0.05). We showed that squamous cell carcinomas led to worse survival than other subtypes. As expected, TNM stage II was significantly correlated with better OS (p = 0.015). Thymic carcinoma is characterised by a KIT-positive and CD5-positive staining pattern. We report a worse overall survival for patients with c-kit expressing tumours. These data suggest a negative prognostic role for c-kit expression especially within the first 5 years.",
author="Terzi, Neslihan
and Yilmaz, Ismail
and Batur, Sebnem
and Yegen, Gulcin
and Yol, Cansu
and Arikan, Evsen
and Oz, Aysim",
pages="120--126",
doi="10.5114/pjp.2020.97019",
url="http://dx.doi.org/10.5114/pjp.2020.97019"
}