@Article{Toh2020,
journal="Clinical and Experimental Hepatology",
issn="2392-1099",
volume="6",
number="3",
year="2020",
title="Intrahepatic splenosis: a world review",
abstract="Splenosis is defined as the autotransplantation of viable splenic tissue throughout various anatomic compartments. Intrahepatic splenosis (IHS) is rare and diagnosis is often challenging. This study aims to provide a comprehensive review on IHS. A literature review was performed on PubMed database. Fifty-six articles with 59 reported cases were included. The majority of the patients were male (n = 49, 83.1%). Median age was 51 years. Risk factors for hepatocellular carcinoma (HCC) included hepatitis B (n = 8, 13.6%) and cirrhosis (n = 12, 20.3%). The majority of the patients were asymptomatic (62.7%) and did not have risk factors for HCC (55.9%). We report a diagnostic triad for IHS: 1) previous history of abdominal trauma or splenectomy, 2) absence of risk factors for liver malignancy and 3) typical imaging features. Non-invasive diagnostic tests such as technetium-99m-tagged heat-damaged red blood cell scintigraphy are useful in diagnosis. Malignancy should be ruled out in the presence of risk factors for HCC.",
author="Toh, Weh Shien
and Chan, Kai Siang
and Lyn Ding, Cristine Szu
and Tan, Cher Heng
and Shelat, Vishal G.",
pages="185--198",
doi="10.5114/ceh.2020.99509",
url="http://dx.doi.org/10.5114/ceh.2020.99509"
}