@Article{Zepeda-Najar2021,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="25",
number="1",
year="2021",
title="Prognostic impact of microsatellite instability in gastric cancer",
abstract="Gastric cancer is a common and deadly cancer. Several factors are associated with its prognosis; however, controversy exists about the role of microsatellite instability (MSI). We aimed to determine the 5-year overall survival (OS) of MSI in gastric adenocarcinoma.   A cross-sectional study was carried out on gastric adenocarcinoma in clinical stages I to III treated with D2 gastrectomy between 2010–2013. MSI was demonstrated by immunohistochemistry. We performed a survival analysis comparing cases with and without MSI.  From 102 cases, 9.8% showed MSI. The median age was 63 years (range 33–91 years), and 57.8% were men. The more prevalent site of occurrence was the antrum (46.1%), 78.5% of the cases presented in stage III, 47.1% were of the diffuse type, 45.1% were of an intestinal type, and 7.8% were mixed. MSI cases were associated with lower clinical stages (stages I–II) and with better 5-year OS (100 vs. 47 months, p = 0.017). In a multivariate analysis, MSI was independently associated with better survival (HR =  0.209, 95% CI: 0.046–0.945, p = 0.042).  MSI gastric cancers presented in early clinical stages and had favourable prognosis compared with non-MSI cancers.",
author="Zepeda-Najar, Cesar
and Xavier Palacios-Astudillo, Rodrigo
and Chávez-Hernández, Jazmín Danaé
and Saul Lino-Silva, Leonardo
and Salcedo-Hernández, Rosa A.",
pages="68--71",
doi="10.5114/wo.2021.104939",
url="http://dx.doi.org/10.5114/wo.2021.104939"
}