@Article{Behling2021,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="59",
number="2",
year="2021",
title="Epigenome-wide data collection in a case of gliofibroma",
abstract="Gliofibroma is a rare tumour entity with glial and mesenchymal histological features. We describe the case of a 30-year-old woman who presented with a short history of intermittent left-sided facial pain and paraesthesia of the left upper extremity. Histologically, the tumour consisted of a mixture of glial fibrillary acidic protein (GFAP)-positive glial cells and collagen-rich stroma. Immunohistochemical and molecular analysis showed no IDH1/2, BRAF, H3F3A mutations or ATP-dependent helicase (ATRX) loss in this tumour. Illumina Infinium HumanMethylation450 BeadChip array (HM450) methylation profile of the tumour was different from typical glioma entities. Genome-wide DNA copy number analysis showed partial loss of chromosome 3 and 8. All previous cases are reviewed. Our data support the classification of gliofibroma as a rare, but distinct brain tumour entity with good prognosis.",
author="Behling, Felix
and Hennersdorf, Florian
and Schittenhelm, Jens",
pages="212--218",
doi="10.5114/fn.2021.106278",
url="http://dx.doi.org/10.5114/fn.2021.106278"
}