@Article{F. Gayyed2021,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="72",
number="1",
year="2021",
title="Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome",
abstract="Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with a high level of mortality and morbidity. In this study we evaluate expression of p-p38 and p-MSK1 in CRC and determine whether there is an association between expression of these markers and any clinicopathologic parameters that could be of prognostic value.   Expression of p-p38, p-MSK1 and ki-67 were examined by immunohistochemistry in 135 archival CRC cases and the findings were correlated with the patient clinicopathological data.  P-p38 and p-MSK1 were expressed at high level in 58.5 % and 60.7% of CRC cases respectively. A statistically significant negative correlation was found between expression of p-p38 and Ki-67 (p < 0.001, r = –0.63) and between p-MSK1 and Ki-67 expression (p < 0.001, r = –0.61). The majority of CRC cases expressing high levels of p-p38 also expressed high levels of p-MSK1 and this correlation was highly significant (p < 0.001, r = 0.863). The high expression of p-p38 and p-MSK1 was also significantly associated with low Dukes and TNM stage. The elevated expression of p-38 and p-MSK1 in CRC was associated with a good prognosis and prolonged overall survival (p < 0.001, each).   Our finding showed that activation of the p38-MSK1 axis determines a good outcome in CRC.",
author="F. Gayyed, Mariana
and Monir Soliman, Medhat
and Fouad Ahmed, Magdy
and Mohamed Hassanin, Taha
and Munir Al Jehani, Rajai
and Zahraa Ammar Mohamed, Fatma El",
pages="39--47",
doi="10.5114/pjp.2021.106442",
url="http://dx.doi.org/10.5114/pjp.2021.106442"
}