@Article{Song2021,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="59",
number="2",
year="2021",
title="MiR-125a-5p silencing inhibits cerebral ischemia-induced injury
through targeting IGFBP3",
abstract="Dysregulated microRNAs (miRNAs) are crucial regulators of cerebrovascular conditions, including ischemic stroke. Circulating miR-125a-5p is associated with ischemic stroke and may have clinical utility as an early diagnostic biomarker. This study conducted a series of experiments that were designed to elucidate the regulatory action of miR-125a-5p in ischemic brain injury and its underlying mechanisms. The results of this study found that the expression of miR-125a-5p was increased in BV2 microglial cells under oxygen-glucose deprivation/reoxygenation (OGD/R) setting, as well as in rat brain tissue after middle cerebral artery occlusion (MCAO). OGD/R triggered BV2 microglial cell apoptosis, whereas downregulation of miRNA-125a-5p suppressed the apoptosis rate in OGD/R-induced BV2 microglial cells. Subsequently, insulin-like growth factor binding protein 3 (IGFBP3) is a molecular target of miR-125a-5p, and IGFBP3 knockdown reversed the effects of miR-125a-5p inhibitor on BV2 microglial cells in vitro. These data supported the fact that miR-125a-5p silencing protects against cerebral ischemia-induced injury by targeting IGFBP3.",
author="Song, Bo
and Xu, Jing
and Zhong, Ping
and Fang, Lei",
pages="121--130",
doi="10.5114/fn.2021.107109",
url="http://dx.doi.org/10.5114/fn.2021.107109"
}