@Article{Zhang2021,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="59",
number="3",
year="2021",
title="Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells",
abstract="Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1.",
author="Zhang, Zhuo
and Yang, Shu-Zhen
and Qi, You-Fu
and Yin, Yong",
pages="239--248",
doi="10.5114/fn.2021.108695",
url="http://dx.doi.org/10.5114/fn.2021.108695"
}