@Article{Saito2022,
journal="Biology of Sport",
issn="0860-021X",
volume="39",
number="4",
year="2022",
title="Genetic profile of sports climbing athletes from three different ethnicities",
abstract="This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552  genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and  HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and  ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies  of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers  than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the metaanalysis on three cohorts showed that the frequency of XX+RX genotypes in the ACTN3 R577X polymorphism  was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X  polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities.",
author="Saito, Mika
and Ginszt, Michał
and Semenova, Ekaterina
and Massidda, Myosotis
and Huminska-Lisowska, Kinga
and Michałowska-Sawczyn, Monika
and Homma, Hiroki
and Cięszczyk, Paweł
and Okamoto, Takanobu
and Larin, Andrey
and Generozov, Edward
and Majcher, Piotr
and Nakazato, Koichi
and Ahmetov, Ildus
and Kikuchi, Naoki",
pages="913--919",
doi="10.5114/biolsport.2022.109958",
url="http://dx.doi.org/10.5114/biolsport.2022.109958"
}