@Article{Soini2022,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="73",
number="1",
year="2022",
title="Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma",
abstract="We investigated the expression of claudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry.   Samples of 164 patients with NSCLC were studied by immunohistochemistry.  Claudin 6 was expressed in 42 % of cases. Its expression was significantly more frequent in adeno- than in squamous cell carcinoma (p = 0.002). There was no association between the TNM status and claudin 6 expression. Claudin 6 associated with a poor prognosis of the patients and with a short recurrence-free interval (p = 0.002, p < 0.001). The association with survival had independent prognostic value (p = 0.011).  The results show that claudin 6 can be regarded as a marker of poor prognosis in lung cancer. This is different to some other cancers, such as breast and cervical carcinoma suggesting that claudin 6 probably induces other cellular pathways in neoplastic lung cells than in those tumors. In lung cancer, adenocarcinomas were most abundantly positive indicating a higher linkage of claudin 6 to glandular differentiation.",
author="Soini, Ylermi
and Pirinen, Risto
and Takasawa, Kumi
and Osanai, Makoto
and Takasawa, Akira",
pages="1--5",
doi="10.5114/pjp.2022.117171",
url="http://dx.doi.org/10.5114/pjp.2022.117171"
}