@Article{Al-Maghrabi2022,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="73",
number="1",
year="2022",
title="Increased Glypican-3 immunostaining is associated with longer survival outcomes in colorectal carcinoma",
abstract="Glypicans (GPC) are involved in the developmental morphogenesis and regulatory processes of cell signalling. Abnormal expression has been observed in different cancer types.   One hundred and thirty-seven colorectal carcinoma (CRC) and 44 nodal metastases were used to create tissue microarrays. Immunohistochemistry was done to detect and evaluate the impact of immunostaining patterns of GPC-3 protein in CRC.  GPC-3 immunostaining is increased in CRC and nodal metastasis (p < 0.001) and was not association with clinicopathological parameters. GPC-3 immunostaining was associated with longer disease-free survival (p = 0.021) and overall survival (p = 0.05).  For the first time, we show GPC-3 immunostaining association with survival outcomes in CRC. GPC-3 may be used as an independent prognostic factor for survival in CRC.",
author="Al-Maghrabi, Jaudah
and Al-Mansouri, Zuhoor
and Al-Harbi, Abdullah
and Assidi, Mourad
and Buhmeida, Abdelbaset
and Gomaa, Wafaey",
pages="14--20",
doi="10.5114/pjp.2022.117172",
url="http://dx.doi.org/10.5114/pjp.2022.117172"
}