@Article{Surmelioglu2022,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="73",
number="1",
year="2022",
title="Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma",
abstract="To evaluate the predictive value of CD44 and aldehyde dehydrogenase 1 (ALDH1) expression for prognosis and radiotherapy (RT) response in patients with early-stage laryngeal cancer receiving RT.  Forty-four patients with early-stage laryngeal cancer diagnosed between 2002 and 2016 were included in the study. The correlation between RT response and pre-treatment immunohistochemical ALDH1 and CD44 staining was evaluated. In addition, survival times were compared between groups.  The mean age of the 44 patients was 59.8 ±9.0 (43-81) years and 41 were male. There were 20 patients in the non-recurrent group (all men) and 24 patients in the recurrent group (21 men). Immunohistochemical positivity for ALDH1 was found to be a significant risk factor for RT failure (p = 0.0001), whereas CD44 positivity (p = 0.114) and age group (p = 0.287) were not significant.   ALDH1 positivity was identified as a significant predictor of DFS and RT sensitivity, while CD44 positivity did not differ according to RT response.",
author="Surmelioglu, Ozgur
and Erdogan, Kıvılcım
and Dagkiran, Muhammed
and Ozdemir, Suleyman
and Tarkan, Ozgur
and Uguz, Aysun",
pages="43--49",
doi="10.5114/pjp.2022.117177",
url="http://dx.doi.org/10.5114/pjp.2022.117177"
}