@Article{Maculewicz2022,
journal="Biology of Sport",
issn="0860-021X",
volume="39",
number="4",
year="2022",
title="The effect of IL10 gene polymorphism on obesity parameters in highly physically active young men",
abstract="The main aim of this study was to investigate the association between 5 polymorphisms of the interleukin 10 (IL10) gene and body composition parameters in physically active young men. A cohort of 131 young men was enrolled and the following IL10 single-nucleotide polymorphisms (SNPs) were analysed: rs1518111, rs1878672, rs3024496, rs3024498 and rs3024505. The subjects were divided into groups depending on obesity parameters: body mass index (BMI) and percentage of body fat tissue (fat %). Statistical analysis was conducted for alleles, genotypes and haplotypes, and an association between SNPs and body composition parameters was analysed using four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI). The only statistically significant result in polymorphisms was found for rs3024505 in the over-dominant model with BMI (p = 0.04) and with fat % (p = 0.02). The haplo.score function showed an association between BMI and CCGTA (respectively) haplotype in the additive model (score = -2.00, p = 0.04) and in the dominant model (score = -2.30, p = 0.02). The obtained results indicate a statistically significant contribution of selected IL10 polymorphisms in the regulation of body weight in physically active individuals.",
author="Maculewicz, Ewelina
and Mastalerz, Andrzej
and Antkowiak, Bożena
and Antkowiak, Oktawiusz
and Garbacz, Aleksandra
and Szarska, Ewa
and Rusin, Paweł
and Cywińska, Anna
and Białek, Agnieszka
and Cięszczyk, Paweł",
pages="1117--1125",
doi="10.5114/biolsport.2023.118336",
url="http://dx.doi.org/10.5114/biolsport.2023.118336"
}