@Article{Mehta2022,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="73",
number="2",
year="2022",
title="Early transformation event from follicular lymphoma: our experience of four cases",
abstract="Follicular lymphoma (FL) is a mature B-cell lymphoma that can transform into a more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation of FL occurs by the acquisition of additional genetic alterations, e.g. c-MYC rearrangement, TP53, and cyclin D1 inactivation. Herein, we describe four such cases of FL that transformed into more aggressive B-cell non-Hodgkin lymphomas within six months of their initial diagnosis. Subsequent testing of c-myc, P53 and cyclin D1 by immunohistochemistry and fluorescence in situ hybridization was done to further analyse their role in the process of transformation.",
author="Mehta, Anurag
and Karki, Diksha
and Gudapati, Prathyusha",
pages="166--175",
doi="10.5114/pjp.2022.120026",
url="http://dx.doi.org/10.5114/pjp.2022.120026"
}