@Article{Machalińska2012,
journal="Klinika Oczna / Acta Ophthalmologica Polonica",
issn="0023-2157",
volume="114",
number="1",
year="2012",
title="The impact of locally administrated VEGF inhibitors on vascular homeostasis – controversies concerning safety of intravitreal therapy in AMD patients",
abstract="Intravitreal vascular endothelial growth factor (VEGF) inhibitors constitutes currently the first-line treatment in neovascular age-  -related macular degeneration (AMD). By intravitreal application of the drug, the dosage can be kept low while maximizing   its effect on choroidal neovascularization and minimizing potential adverse systemic effects. However, the eye-blood barrier is   often disrupted in ophthalmic neovascular disorders and the drugs can be detected in circulating blood despite being administered as an intraocular injection. As patients with AMD constitute a high-risk population for cardiovascular events, the safety   of anti-VEGF therapies must be precisely and thoroughly assessed. In the present work, the recent reports documenting systemic safety of intravitreal VEGF inhibitors have been reviewed. Moreover, the novel methods to assess the potential systemic   effect on vascular homeostasis as the consequence of such therapy have been also discussed.",
author="Machalińska, Anna",
pages="63--67",
url="https://www.termedia.pl/The-impact-of-locally-administrated-VEGF-inhibitors-on-vascular-homeostasis-controversies-concerning-safety-of-intravitreal-therapy-in-AMD-patients,124,48351,1,1.html"
}