@Article{Za­lew­ska2004,
journal="Klinika Oczna / Acta Ophthalmologica Polonica",
issn="0023-2157",
volume="106",
number="4",
year="2004",
title="The expression of Bcl-2, Bcl-xl, Bak and Bax proteins in axons
of the optic nerve in absolute glaucoma",
abstract="Purpose: The aim of our study was the evaluation of Bcl-2, Bcl-xl, Bak and Bax immunoexpression in axons of the optic nerve   with absolute glaucoma.   Material and methods: This study was conducted on 19 patients with absolute glaucoma, suffered from severe ophthalmalgia,   treated of necessity by enucleation in 1991-2003 in our Department of Ophthalmology. The samples were immuno-stained with   antibodies for Bcl-2, Bak, Bax and Bcl-xl protein. The reactions were performed in Labelled Streptavidin Avidin Biotin (LSAB)   technique. The evaluation of immuno-staining was calculated as the percentage of cells with positive reaction to the total   number of cells encountered in 10 representative fields, by light microscopy using a x 20 objective lens. Scores were based on   the following scale: (++), over 50% of the field showing positive immuno-staining, (+) 10-50% with positive immunostaining.   Results: In our study proapoptotic Bak and Bax protein expression was stronger than antiapoptotic Bcl-2, Bcl-xl protein   expression; Bak/Bcl-2 (p = 0,008), Bax/Bcl-2 (p = 0,0007), Bak/Bcl-xl (p = 0,0356), Bax/Bcl-xl (p = 0,0077).  Conclusions: The results of our study demonstrate high proapoptotic trends in axons of the optic nerve in the stage of absolute   glaucoma.",
author="Za­lew­ska, Re­na­ta
and Re­szeć, Jo­an­na
and Mariak, Zofia
and Sul­kow­ski, Sta­nisław",
pages="155--157",
url="https://www.termedia.pl/The-expression-of-Bcl-2-Bcl-xl-Bak-and-Bax-proteins-in-axons-r-nof-the-optic-nerve-in-absolute-glaucoma,124,49045,1,1.html"
}