@Article{Yetişir2022,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="73",
number="4",
year="2022",
title="Sarcoma – correlation between CD73 and PD-L1 and their relationship with prognosis",
abstract="This study aimed to evaluate CD73 and PD-L1 and determine their relationship with each other and with overall survival (OS) in sarcoma patients.   The paraffin blocks of 101 patients were analysed. 56.4% were female, and the mean age was 51.39 years. The mean OS was 20.73 months, and the Ki-67 proliferative index was 41.45. A positive correlation was found between CD73 tumour and CD73 tumour-infiltrating lymphocyte (TIL) findings. CD73 tumour and TIL findings were also positively correlated with PD-L1 percentages and  PD-L1 intensity.   An inverse correlation was detected between OS and CD73 tumour and TIL groups of 5–25%, 25–50%, 50–75%, 75–90%, and > 90%, but no such correlation was found for the ≤ 5% group. There was an inverse correlation between OS and the PD-L1 percentages of   50% and the PD-L1 intensity of weak-moderate and strong, but no correlation was found for the negative values. Lastly, an inverse correlation was found between OS and the Ki-67 proliferative index.   We found CD73 and PD-L1 positivity to be associated with decreased OS in sarcoma patients and determined a significant correlation between these parameters. This result is promising in terms of achieving better survival and disease control with anti-CD73 and anti-PD-L1 therapy in selected patients.",
author="Yetişir, Abdullah Evren
and Paydaş, Semra
and Gönlüşen, Gülfiliz
and Erdoğan, Kıvılcım Eren
and Büyükşimşek, Mahmut
and Oğul, Ali
and Tohumcuoğlu, Mert
and Mirili, Cem
and Yetişir, Ayşegül",
pages="338--342",
doi="10.5114/pjp.2022.125537",
url="http://dx.doi.org/10.5114/pjp.2022.125537"
}