@Article{Özdemiral2023,
journal="Alergologia Polska - Polish Journal of Allergology",
issn="2353-3854",
volume="10",
number="1",
year="2023",
title="D-dimer elevation during tranexamic acid therapy
and the debate on the therapeutic approach in hereditary
angioedema type I",
abstract="Hereditary angioedema type 1 (HAE-1) is the most prevalent HAE type, and it results from decreased antigenic C1 inhibitor (C1-INH) levels or function. Bradykinin-mediated angioedema in the face, trunk, extremities, genitalia, gastrointestinal tract, and upper airway are the symptoms of this rare and potentially fatal disease. PD-C1-INH concentrates, recombinant C1-INH, tranexamic acid (TXA), danazol, icatibant, ecallantide, and fresh-frozen plasma (FFP) may be used for treatment. The focus of this article is to point out D-dimer elevation during TXA use. We detected d-dimer elevation incidentally in 2 patients with hereditary angioedema (HAE) type 1 during tranexamic acid (TXA) therapy, in whom elevations were normalized a week after suspended TXA. However, the TXA treatment is expected to decrease D-dimer levels in surgery and hyperfibrinolysis. On the other hand, although using TXA in long-term prophylaxis in HAE treatment is not recommended, we observed that 2 patients had significant reduction of their attack frequency for over a year.",
author="Özdemiral, Cansu
and Cagdas, Deniz",
pages="63--67",
doi="10.5114/pja.2023.125770",
url="http://dx.doi.org/10.5114/pja.2023.125770"
}