@Article{Lasota2024,
journal="Klinika Oczna / Acta Ophthalmologica Polonica",
issn="0023-2157",
volume="126",
number="1",
year="2024",
title="Corneal trophic ulcer one week after topical diclofenac use",
abstract="A 65-year-old woman operated on for cataract was discharged from hospital with a routine prescription including diclofenac. One week later she was diagnosed with corneal trophic ulcer in the operated eye. As the non-operated eye suffered from filamentary keratopathy, the hypothesis of a serious adverse event due to diclofenac was considered. Diclofenac was stopped and intensive topical non-preservative tears were administered. No further melting was noticed and epithelialization of the cornea occurred. Diclofenac as a non-steroidal anti-inflammatory drug is known for its anesthetic action on the cornea. This effect contributes to aggravation of the pre-existing dry eye syndrome related to Sjögren syndrome (diagnosed a posteriori) with potential for corneal perforation. Therefore the prescription of diclofenac should be preceded by questioning the patient about the predisposing rheumatoid conditions and careful examination of the eye.",
author="Lasota, Piotr",
pages="45--47",
doi="10.5114/ko.2023.133114",
url="http://dx.doi.org/10.5114/ko.2023.133114"
}