@Article{Skalska2023,
journal="Alergologia Polska - Polish Journal of Allergology",
issn="2353-3854",
volume="10",
number="4",
year="2023",
title="Participation of reactive oxygen species in the pathogenesis of food allergies",
abstract="There has been a significant increase in the incidence of allergic diseases for several decades. There is even a talk of “an epidemic of the 21 st  century” in relation to, for example, food allergies (FAs). Modern lifestyle and environmental factors contribute to a further increase in disease incidence. The authors proved that the first three years of life are a very important period for the proper development of microflora and taking actions in the context of prevention/therapy; and antibiotic therapy and diet play a significant role in shaping a stable microbiota. An adverse immune reaction to food is referred to as a FA. Immune reactions to food allergens can generally be divided into: IgE-mediated, non-IgE-mediated and mixed. Reactive oxygen species (ROS) are involved in the pathogenesis of FAs. Oxidative stress induces inflammation in tissues; excessive amounts of ROS damage intestinal tissue, disrupt normal cell function, and in eosinophilic esophagitis (EoE) impair the Keap1/Nrf2 pathway.",
author="Skalska, Magdalena
and Kleniewska, Paulina
and Pawliczak, Rafał",
pages="280--285",
doi="10.5114/pja.2023.133771",
url="http://dx.doi.org/10.5114/pja.2023.133771"
}