@Article{Bursch2005,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="43",
number="4",
year="2005",
title="ORGINAL ARTICLEAutophagy \– a basic mechanism and a potential role for neurodegeneration",
abstract="Autophagy constitutes a fundamental survival strategy of cells; its disturbance contributes to the pathogenesis of cancer, liver and immune disease, pathogen infection, myopathies as well as neurodegenerative disorders such as Amyotrophic lateral sclerosis, Parkinson`s, Huntington`s and Alzheimer`s disease. The pathogenesis of neurodegenerative diseases also involves a gradual and progressive loss of neuronal cells. Cells may use different pathways for active self-destruction as reflected by different morphology: while in apoptosis (or \“type I\”) nuclear fragmentation associated with cytoplasmic condensation but preservation of organelles is predominant, autophagic degradation of the cytoplasmic structures preceding nuclear collapse is a characteristic of a second type of programmed cell death (PCD). Linking autophagy to programmed cell death initiated a controversial discussion on how a suggested role of autophagy in cell suicide might meet with its established survival function. To some extent, the diverse morphologies can be associated with distinct biochemical and molecular events [caspase-dependent and -independent death programs, DAP-kinase activity, Ras-expression, induction of autophagy genes, fate of cytoskeleton, among others]. However, there is a broad overlap between cell death pathways. Conceivably, diverse PCD programs emerged during evolution, the conservation of which allows eukaryotic cells a flexible response to physiological or pathological demands.",
author="Bursch, Wilfried
and Ellinger, Adolf",
pages="297--310",
url="https://www.termedia.pl/ORGINAL-ARTICLE-Autophagy-8211-a-basic-mechanism-and-a-potential-role-for-neurodegeneration,20,5373,1,1.html"
}