@Article{Poter2024,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="75",
number="2",
year="2024",
title="Association of PD-1 and PD-L1 protein expression with selected clinical and morphological parameters in colorectal cancers",
abstract="Colorectal cancer is the third most common cancer worldwide and the second cause of death from malignant tumors. Colorectal cancers are treated with surgery, chemotherapy, gene therapy and immunotherapy. PD-1 and PD-L1 proteins have recently been considered as potential targets of anticancer therapy in colorectal cancer. The aim of this study was to evaluate the association of immunohistochemical expression of PD-1 and PD-L1 proteins in colorectal cancer patients with selected clinical and morphological parameters and their survival. Ninety-eight cases of colorectal cancer were studied.   Immunohistochemistry was used to evaluate the expression of PD-1 and PD-L1 proteins.   Correlations were found between the expression of PD-L1 protein in lymphocytes and lack of lymph node metastases and a lower clinical stage.   There was also a correlation between PD-L1 protein expression in cancer cells and a higher grade of histological malignancy.",
author="Poter, Paulina
and Jankowska-Szabłowska, Sylwia
and Kolenda, Tomasz
and Dobak, Ewa
and Urasińska, Elżbieta
and Karpińska-Łukaszewicz, Katarzyna",
pages="105--114",
doi="10.5114/pjp.2024.139935",
url="http://dx.doi.org/10.5114/pjp.2024.139935"
}