@Article{Yang2024,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="75",
number="3",
year="2024",
title="ANRIL regulates retinoblastoma progression via targeting autophagy by miR-328-3p/TSC1/ULK signaling",
abstract="Retinoblastoma is the most common primary intraocular malignancy of childhood. The aim of our study was to investigate the role and regulatory mechanism of the long non-coding RNA ANRIL in retinoblastoma.   Here, our data demonstrated that ANRIL overexpression inhibited miR-328-3p expression, but promoted expression of autophagy-related proteins (LC3B, ATG5, and BECN1). Then we predicted the binding sites for ANRIL with miR-328-3p, and for miR-328 3p with TSC1/ULK2 3′-UTR, and confirmed the combination of miR-328-3p and ANRIL and TSC1/ULK2 3′-UTR. Importantly, the data showed that ANRIL overexpression promoted TSC1 and ULK2 expression, and inhibited the phosphorylation of mTOR. Finally, our results indicated that ANRIL overexpression facilitated Y79 cell proliferation and cisplatin-induced apoptosis.  Our results indicated that ANRIL promoted the proliferation and cisplatin resistance of Y79 cells through activating autophagy by promoting TSC1/ULK2 ex- pression via acting as a miR-328-3p sponge.",
author="Yang, Yang
and Zhang, Yuezhi
and Fu, Yanmei
and Li, Shuanglian
and Yin, Xiaolong",
pages="228--235",
doi="10.5114/pjp.2024.142177",
url="http://dx.doi.org/10.5114/pjp.2024.142177"
}