@Article{Rell-Bakalarska2006,
journal="Reumatologia/Rheumatology",
issn="0034-6233",
volume="44",
number="1",
year="2006",
title="ORIGINAL ARTICLELeflunomide in treatment of RA patents preliminary estimation of therapeutical efficiency and side effects",
abstract="In the preliminary estimation there were studied efficiency and safety of therapy leflunomid in patients with RA. The drug was given p. o. to a group of 158 patients (150 females and 8 males) for 3 days 100 mg/24 h, and then again 20 mg/24 h.  The age of patients varied between 19-78 (average age was 55 years), with average duration time of the disease 10 years and 2 months. All of the patients were previously unsuccessfully treated with other DMARDS. All of the patients had high activity of disease estimated by DAS 28 \≥5.1 61.4% of patients were treated with long-term glicocorticosteroids. Time of trial was scheduled for 6 months. The therapeutical effect was initially estimated on the basis of a group of 43 patients who took the medicine for 91-120 days.  Good and average therapeutical efficiency of treatment was observed in 76.73% of patients. Efficiency was expressed by lowering DAS 28 by 0.6-1.2 in a group of 11.62% of patients and 1.2 in a group of 65.11% of patients. In a group of 3.79% of patients the treatment was stopped because of complete lack of therapeutical effect.  Frequency of side effects was initially estimated in a group of 158 patients.  Treatment was interrupted in the group of 8.86% of patients because of such side effects as: diarrheas, elevation of transaminazes, leukopenia and trombocytopenia, skin changes and dizziness. Observations are continued. Preliminary results of observations allow for positive evaluation of treatment with leflunomid in RA patients.",
author="Rell-Bakalarska, Maria
and Jaworski, Janusz
and Rutkowska-Sak, Lidia
and Wieczorek, Małgorzata
and Kwiatkowska, Małgorzata
and Klimczak, Ewa
and Kowalczuk, Bożena
and Rell, Krzysztof Wojciech",
pages="19--25",
url="https://www.termedia.pl/ORIGINAL-ARTICLE-Leflunomide-in-treatment-of-RA-patents-preliminary-estimation-of-therapeutical-efficiency-and-side-effects,18,5478,1,1.html"
}