@Article{Noworyta2006,
journal="Reumatologia/Rheumatology",
issn="0034-6233",
volume="44",
number="1",
year="2006",
title="ORIGINAL ARTICLEThe presence of endotoxin in synovial fluids from connective tissue diseases (Ctd-s) patients with as a suspected disease aethiological marker",
abstract="The aim of the study was to show the presence of endotoxin in the synovial fluids from the patients suffering of Ctd-s (in prevalence RA and other undifferentiated joint arthritis).  The usefulness of the applied LAL-test (Limulus Amebocyte Lysate) was evaluated (just in endotoxin /LPS/ assessment), as a main and functionally most important of the Gram-negative bacterial cell wall component.  It was proved, that in the group of 50 synovial fluids from Ctd-s patients 42% was LAL-positive (with presence of endotoxin) and in 60% of RA patients LAL-test was also positive.  Simultaneously, in the total amount of LAL-negative synovial fluids we found, that in 66.6% the inhibiting LAL-test substances (including antibody) have been found. It suggest, that in tested material we have obtained considerable amount of the fals-negative tests (results), because that a retrospective analysis showed in tested synovial fluids the presence of anti-LPS or antibodies to selected LPS subcomponents up to 80%.  In discussion a possible influence of endotoxin, especially bacilli from genus Salmonella enteritidis (or S. typhimurium) and their toxic component (lipid A) on the induction acute phase Ctd-s (especially in RA and undifferentiated inflammation of joints) \– basing on our own experiments and literature, was touched.",
author="Noworyta, Jacek
and Ząbek, Jakub
and Brasse-Rumin, Maria
and Gago, Jolanta
and Rell-Bakalarska, Maria",
pages="26--33",
url="https://www.termedia.pl/ORIGINAL-ARTICLE-The-presence-of-endotoxin-in-synovial-fluids-from-connective-tissue-diseases-Ctd-s-patients-with-as-a-suspected-disease-aethiological-marker,18,5479,1,1.html"
}