@Article{Teoman2024,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="75",
number="4",
year="2024",
title="Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer",
abstract="The enzyme phosphatidylinositide-3-kinase (PI3K) regulates cellular proliferation and apoptosis. Somatic mutations in the  PIK3CA  gene can accelerate these processes and significantly contribute to the development and progression of breast cancer. This study aimed to ascertain the  PIK3CA  gene mutations in breast cancer patients and investigate their correlation with certain clinicopathological characteristics.  We conducted a mutational investigation of the  PIK3CA  gene using next-generation sequencing (NGS) in a sample of 100 cases of primary breast cancer. We investigated the associations between  PIK3CA  mutations and clinicopathological characteristics.  Our analysis revealed a mutation rate of 45% in the  PIK3CA  gene. The mutation frequencies for the three hotspot sites were 33.3% for E545K in exon 10, 26.7% for H1047R in exon 20, and 6.7% for E542K in exon 10. Of the 45 individuals with tumors carrying the  PIK3CA  mutation, 41 (91.2%) had only one mutation, while 4 (8.8%) had two. Pathogenic  PIK3CA  mutations were significantly correlated with tumor size ( p  = 0.015) and tumor location ( p  = 0.017).  Our study results demonstrated a significant association between tumor size, location, and presence of the  PIK3CA  mutation. We must validate these data in larger sample sizes.",
author="Teoman, Gizem
and Usta, Zeynep Turkmen
and Yilmaz, Zeynep Sagnak
and Mungan, Sevdegul Aydin
and Saygin, Ismail",
pages="268--273",
doi="10.5114/pjp.2024.145702",
url="http://dx.doi.org/10.5114/pjp.2024.145702"
}