@Article{Majchrzycka2025,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="42",
number="1",
year="2025",
title="Interleukins 30 and 27 in psoriasis and inflammation",
abstract="This review explores the roles of interleukin-30 (IL-30) and interleukin-27 (IL-27) in inflammation and autoimmune diseases, with a focus on psoriasis. The two coexisting cytokines should be analysed in conjunction as their actions are antagonistic in vivo. While IL-27 exhibits diverse anti-inflammatory mechanisms, the understanding of IL-30’s functions remains limited. Studies suggest that IL-27 may play a role in regulating psoriasis, but findings are inconsistent. IL-30 shows promise in mitigating psoriatic lesions and suppressing inflammatory responses. However, research on IL-30’s involvement in autoimmune diseases presents conflicting results. This article provides a literature review on the complex correlations between cytokines, their role in the pathogenesis of psoriasis, inflammation, carcinogenesis, and autoimmune diseases, and provides a detailed picture of the interplay between IL-27 and IL-30 to uncover novel therapeutic targets for psoriasis and other autoimmune conditions.",
author="Majchrzycka, Marianna
and Wegner, Joanna
and Adamski, Zygmunt
and Jenerowicz, Dorota",
pages="1--4",
doi="10.5114/ada.2025.147548",
url="http://dx.doi.org/10.5114/ada.2025.147548"
}