@Article{Mehmood2025,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="29",
number="3",
year="2025",
title="LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition",
abstract="Retrotransposable elements are harmful at several levels, and host surveillance systems fail to consider all these elements in severe effects. The key role of retrotransposon in aging and age-associated diseases remains unclear. We summarise whether LINE-1 retrotransposable elements transcriptionally derepress and activate type-I interferon response during cellular senescence. Type-I interferon response is the late senescence phenotype that maintains the senescence-associated secretory phenotype. Cytoplasmic LINE-1 cDNA activates type-I interferon response, while LINE-1 reverse transcriptase inhibitors suppress it. The nucleoside reverse transcriptase inhibitor lamivudine downregulates activation of type-I interferon and age-associated inflammation in tissues in the treatment of aging. Activation of retrotransposons is a key factor in sterile inflammation, which is a hallmark of aging, and LINE-1 reverse transcriptase is an important target for the treatment of age-associated diseases. Nucleoside reverse transcriptase inhibitor lamivudine downregulates activation of type-I interferon and age-associated inflammation.",
author="Mehmood, Arshad
and Xue, Yue Zhu
and Yassin, Habab Merghani
and Zubair, Mohammad
and Rahmat, Syed Adnan
and Ahmad, Aftab",
pages="240--246",
doi="10.5114/wo.2025.152369",
url="http://dx.doi.org/10.5114/wo.2025.152369"
}