@Article{Karczewska2001,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="5",
number="1",
year="2001",
title="BRCA2 mutation analysis in male breast cancer patients in Poland",
abstract="Breast cancer is a rare disease in men. Germ-line mutations in BRCA2 and androgen receptor (AR) genes are thought to be responsible for a proportion of male breast cancer cases. The present study was performed on a series of 38 consenting patients not selected for family history of breast/ovarian cancer. The entire coding region of the BRCA2 gene was analyzed for germ-line mutations to evaluate the association between BRCA2 gene and male breast cancer in Poland. We identified five frameshift mutations (13%) and five missense unclassified variants (13%) of the BRCA2 gene. The frequencies of missense alterations were examined in a set of 200 chromosomes. Six of 38 patients (16%) had a family history of breast cancer, in one first- or second-degree relative, including two mutation carriers. The results of this study suggest that germ-line BRCA2 mutations account for moderate proportion of male breast cancer in Poland.",
author="Karczewska, Aldona
and Mackiewicz, Andrzej
and Bręborowicz, Danuta
and Godlewski, Dariusz
and Kwiatkowska, Eliza
and M. Lamperska, Katarzyna
and Teresiak, Marek
and Stawicka, Małgorzata
and J. Krzyżosiak, Włodzimierz",
pages="5--8",
url="https://www.termedia.pl/BRCA2-mutation-analysis-in-male-breast-cancer-patients-in-Poland,3,564,1,1.html"
}