@Article{Obtułowicz2025,
journal="Alergologia Polska - Polish Journal of Allergology",
issn="2353-3854",
volume="12",
number="3",
year="2025",
title="Early and late allergic reactions limited to adalimumab injection sites in a patient with severe plaque psoriasis",
abstract="Tumor necrosis factor-α (TNF-α) inhibitors, such as adalimumab, are widely used for the treatment of various inflammatory diseases, including psoriasis. Injection site reactions (ISRs) are common side effects, typically mild and self-limiting. Nevertheless, in some cases, ISRs may persist or evolve into more severe hypersensitivity reactions, requiring discontinuation or a change of the therapy. We present the case of a 40-year-old woman with plaque psoriasis who developed progressive ISRs and recall reactions during adalimumab therapy. Allergological diagnostics confirmed a delayed-type hypersensitivity reaction. Transitioning to an IL-12/IL-23 inhibitor resulted in clinical improvement, highlighting the importance of allergological testing and alternative biologic therapies.",
author="Obtułowicz, Aleksander
and Barouka, Daryna
and Kapusta, Dominika
and Kapczyński, Norbert
and Lato, Marta
and Jaworek, Andrzej
and Obtułowicz, Bartosz
and Wojas-Pelc, Anna",
pages="227--231",
doi="10.5114/pja.2025.153695",
url="http://dx.doi.org/10.5114/pja.2025.153695"
}