@Article{Dai2025,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="76",
number="3",
year="2025",
title="Clinicopathological features of anaplastic lymphoma kinase-rearranged lung adenocarcinoma initially misdiagnosed with invasive mucinous adenocarcinoma – a retrospective study",
abstract="Anaplastic lymphoma kinase (ALK) rearranged lung adenocarcinoma is frequently characterised by prominent mucin secretion and a heterogeneous population of mucinous cells. These histological features may result in misdiagnosis as invasive mucinous adenocarcinoma.   We conducted a comprehensive analysis of 4 cases of ALK-rearranged lung adenocarcinoma, focusing on the clinicopathological features, genetic mutations, and clinical outcomes. Among these cases, 3 cases were initially diagnosed as invasive mucinous adenocarcinoma, while one case was identified as recurrent invasive mucinous adenocarcinoma. The cohort comprised 3 female and 1 male patient/s, with ages ranging from 47 to 63 years (mean age 54.8 years).   The tumour cells exhibited sieve-like tubular and solid signet ring structures, with evidence of intracytoplasmic and extracellular mucin secretion. Immunohistochemical analysis demonstrated diffuse expression of TTF-1, Napsin A, and ALK(D5F3) in tumour cells, while HNF4a, CK20, and MUC5AC were consistently negative.   Next-generation sequencing analysis confirmed ALK rearrangements in 3 cases. Accurate identification of this specific subtype of lung adenocarcinoma is essential for administering appropriate treatment and reducing the risk of potential misdiagnosis.",
author="Dai, Xiaomin
and Feng, Xiaoyue
and Lu, Yanbo
and Peng, Fang",
pages="187--194",
doi="10.5114/pjp.2025.155788",
url="http://dx.doi.org/10.5114/pjp.2025.155788"
}