@Article{Mhamdi2026,
journal="Biology of Sport",
issn="0860-021X",
volume="43",
number="1",
year="2026",
title="Aging reimagined: Bridging clinical modulation and scientific 
breakthroughs",
abstract="The expanding body of research that suggests aging may be controllable is examined in our literature review, drawing on insights from certain domains where physiological degeneration is potentially modifiable. The discovery of telomerase and its connection to cellular senescence, the epigenetic reprogramming of adult cells into pluripotent states, and the role of autophagy in longevity are encouraging scientific milestones, as they address key signaling pathways of aging including rapamycin, adenosine monophosphate-activated protein kinase, and forkhead box O transcription factors. Clinical innovations involving growth hormone, metformin, and dehydroepiandrosterone have shown demonstrable modifiable biological age’s markers, as evidenced by the thymus regeneration, immunorestoration, and insulin mitigation experiment. Furthermore, lifestyle-based tactics such as stress management, dietary optimization, exercise, and circadian alignment have become widely available resources for extending life expectancy. Sleep disturbance, poor nutrition, and psychological stress are key factors in the relationship between accelerated aging on one hand and persistent low-grade inflammation and metabolic dysfunction on the other hand (ie, inflammaging and metaflammation concepts). The advent of targeted therapies (eg, senotherapeutics and Sirtuin activators) and precision medicine tools (eg, polygenic risk scores and multi-cancer early detection tests) further highlight an ongoing shift from reactive to preventive medicine. While ethical and regulatory challenges—particularly regarding equitable access and long-term safety— are yet to be fully addressed, there is consensus that aging is a dynamic process open to intervention. This literature review urges researchers, physicians, and legislators to prioritize aging research, support translational initiatives, and integrate evidence-based treatments into public health frameworks.",
author="Mhamdi, Salah
and Chamari, Karim
and BaHammam, Ahmed
and Alkeridy, Walid
and Aldeeri, Abdulrahman
and Ben Saad, Helmi",
pages="617--630",
doi="10.5114/biolsport.2026.156224",
url="http://dx.doi.org/10.5114/biolsport.2026.156224"
}