@Article{Li2026,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="64",
number="1",
year="2026",
title="The role of synaptic plasticity in Alzheimer’s disease: from molecular mechanisms to therapeutic targets",
abstract="Alzheimer’s disease (AD) is characterized by a complex pathophysiology, involving abnormal aggregation of amyloid b (Ab) and tau proteins, neuroinflammatory responses, and significant synaptic dysfunction, which collectively contribute to cognitive decline. This review offers a novel perspective by focusing on the pivotal role of synaptic plasticity in the pathogenesis of AD, underscoring its potential as a therapeutic target. The study uniquely synthesizes current molecular and clinical research to illustrate how Ab and tau pathologies disrupt synaptic signaling and structure, further exacerbated by neuroinflammation. We explore both pharmacological interventions, such as BACE1 inhibitors and tau stabilizers, and non-pharmacological strategies, including cognitive therapy and neuromodulation techniques, which have shown promise in modulating synaptic plasticity and slowing cognitive deterioration. Despite these advancements, the field faces significant challenges, including the complexity of AD’s underlying mechanisms and limitations in early diagnosis. This review not only highlights the significance of synaptic plasticity in AD but also proposes future research directions that could lead to innovative therapeutic approaches, offering new hope for effective treatment strategies.",
author="Li, Yunyun
and Li, Sichong
and Ma, Jing
and Zhao, Jing
and Ning, Ning
and Sun, Jianfang",
pages="1--11",
doi="10.5114/fn.2025.156508",
url="http://dx.doi.org/10.5114/fn.2025.156508"
}