@Article{Diao2026,
journal="Biology of Sport",
issn="0860-021X",
year="2026",
title="The association between domain-specific physical activity 
in adults and Parkinson’s disease and all-cause mortality: 
a NHANES study from 2007 to 2018",
abstract="This study aimed to examine the associations between physical activity (PA) of different domains and	intensities	with	the	risk	of	Parkinson’s	disease	(PD)	and	all-cause	mortality	among	adults	aged	40 years	and	older.	A total	of	13,960 participants	from	the	National	Health	and	Nutrition	Examination	Survey	(NHANES)	2007–2018 were	included.	Multivariable	logistic	regression	models	were	used	to	evaluate	the	associations	between	PA	and	PD	prevalence.	Kaplan–Meier	survival	curves	with	log-rank	tests	were	applied	to	compare	mortality	across	PA	categories,	and	Cox	proportional	hazards	models	were	employed	to	assess	the	joint	effects	of	PA	and	PD	on	all-cause	mortality.	Sex-stratified	subgroup	analyses	and	multiple	sensitivity	analyses	were	also	performed	to	confirm	the	robustness	of	the	findings.	After	adjustment	for	potential	confounders,	vigorous	occupational	PA	(OPA)	(OR = 0.349,	95%	CI:	0.181–0.674)	and	total	vigorous	PA	(OR = 0.471,	95%	CI:	0.260–0.853)	were	inversely	associated	with	PD	prevalence.	Survival	analyses	demonstrated	that	higher	levels	of	PA,	regardless	of	domain	or	intensity,	were	significantly	associated	with	lower	mortality.	Consistent	results	were	observed	in	Cox	regression	models,	where	adherence	to	moderate	or	vigorous	PA	was	associated	with	a 29.5%	(HR = 0.705,	95%	CI:	0.638–0.7781)	and	29.0%	(HR = 0.710,	95%	CI:	0.610–0.826)	reduction	in	mortality	risk,	respectively.	Among	participants	with	PD,	those	not	engaging	in	vigorous	OPA	(HR = 1.483,	95%	CI:	1.134–1.940)	or	total	vigorous	PA	(HR = 1.504,	95%	CI:	1.150–1.968)	had	significantly	higher	mortality	than non-PD individuals, whereas those who were physically active exhibited mortality risks comparable to their	non-PD	counterparts.	Sensitivity	analyses	yielded	consistent	results,	supporting	the	robustness	of	these	associations.	Vigorous	occupational	and	total	vigorous	physical	activity	were	inversely	associated	with	both	PD	prevalence	and	all-cause	mortality	among	adults	aged ≥ 40 years.	Moreover,	adherence	to	vigorous	PA	among	individuals	with	PD	may	mitigate	the	excess	mortality	risk	associated	with	the	disease.	Nevertheless,	prospective	cohort	studies	are	warranted	to	confirm	these	findings	and	clarify	the	underlying	mechanisms.",
author="Diao, Wenwen
and Tang, Shunxiong",
pages="795--813",
doi="10.5114/biolsport.2026.158669",
url="http://dx.doi.org/10.5114/biolsport.2026.158669"
}