@Article{Kwiecinska2026,
journal="Pediatria Polska - Polish Journal of Paediatrics",
issn="0031-3939",
volume="101",
number="1",
year="2026",
title="Treatment-related toxicities in acute lymphoblastic leukemia in a child with Marfan syndrome: a case report",
abstract="Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene. Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. The coexistence of MFS and ALL is rare and presents a unique clinical challenge. We report the case of an 8.5-year-old boy with MFS who developed precursor B-cell acute lymphoblastic leukemia with the ETV6-RUNX1 fusion gene. He achieved complete remission with initial chemotherapy. Two years later, he experienced a relapse involving the testes and central nervous system. Subsequent treatment led to severe complications. Whole exome sequencing revealed multiple pathogenic variants, including a CHEK2 mutation, potentially contributing to the malignancy and treatment-related toxicities. This case highlights the potential role of dysregulated transforming growth factor β signaling in MFS contributing to leukemogenesis. The patient’s severe complications and co-occurrence of MFS underscore the need for personalized therapeutic strategies and comprehensive, multidisciplinary care. Further research is essential to improve clinical outcomes.",
author="Kwiecinska, Kinga
and Czogała, Wojciech
and Żurek, Kacper Szczepan
and Kaleta, Konrad
and Możdżeń, Kamil
and Murawska, Agnieszka
and Skoczeń, Szymon",
pages="95--104",
doi="10.5114/polp.2026.160465",
url="http://dx.doi.org/10.5114/polp.2026.160465"
}