@Article{Aydin2026,
journal="Polish Journal of Pathology",
issn="1233-9687",
year="2026",
title="Prognostic impact of tumour budding, stromal phenotype, and CD163-positive macrophages  in intestinal-type gastric adenocarcinoma",
abstract="The tumour microenvironment plays an important role in the progression of gastric adenocarcinoma, but the prognostic value of its histopathological and immunological components in intestinal-type tumours remains unclear.   This retrospective study included 100 patients who underwent gastrectomy for intestinal-type gastric adenocarcinoma.   Tumour budding, stromal phenotype, tumour-stroma ratio, and lymphocytic infiltration were assessed on haematoxylin-eosin-stained sections, and immunohistochemical analyses of CD68, CD163, L-caldesmon, and periostin were performed at the invasive front. Tumour budding was associated with invasion depth and tumour stage but showed no independent prognostic significance. A myxoid stromal phenotype was independently associated with improved overall survival and reduced recurrence risk. CD163-positive macrophage density exceeded CD68 density and was independently linked to better survival. L-caldesmon expression was rare and not associated with clinicopathological parameters. Periostin expression correlated with macrophage infiltration but not with survival outcomes.   These findings suggest that stromal phenotype and tumour-associated macrophages, particularly CD163-positive cells, have prognostic relevance in intestinal- type gastric adenocarcinoma.",
author="Aydin, Elİf
and Atmış, Ömer
and Mavİlİ, Hanİfe Seda
and Şahbazlar, Mustafa
and Ayhan, Semİn",
doi="10.5114/pjp.2026.161702",
url="http://dx.doi.org/10.5114/pjp.2026.161702"
}