@Article{Krakowiak2026,
journal="Medical Studies/Studia Medyczne",
issn="1899-1874",
year="2026",
title="Boron neutron capture therapy – a brief review of principles and clinical applications",
abstract=" Boron neutron capture therapy (BNCT) exploits alpha and lithium particles produced in the boron-10 fission reaction (10B(n,)7Li) with epithermal neutrons to inactivate cancer cells in the tumour volume ranges of produced alpha and lithium particles are limited to individual cells, so the boron-10 atoms should be located only in the target cancer cells. First, there is a need to administer to the patient the boron-10 carrier, which selectively deposits boron-10 atoms in cancer cells. Next, an external beam of epithermal neutrons must be delivered to the treated volume. BNCT is thus a bimodal method, combining epithermal neutron beam teletherapy with systemic therapy. Although BNCT is still under development, recent advances in boron-10 delivery agents and in accelerator-based epithermal neutron beam generation offer a new perspective for BNCT. These advances and some clinical applications of BNCT are briefly reviewed. ",
author="Krakowiak, Wiktoria E.
and Wójciuk, Karolina
and Dorosz, Michał
and Płódowska, Magdalena A.
and Pasińska, Kinga
and Węgierek-Ciuk, Aneta
and Lankoff, Anna
and Wojcik, Andrzej
and Lisowska, Halina",
doi="10.5114/ms.2026.162327",
url="http://dx.doi.org/10.5114/ms.2026.162327"
}