@Article{Lisowska2006,
journal="Reumatologia/Rheumatology",
issn="0034-6233",
volume="44",
number="2",
year="2006",
title="Review paperThe ups and downs of non-steroidal anti-inflammatory drugs",
abstract="Conventional non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the metabolism of arachidonic acid to proinflammatory prostaglandins (PGs) by cyclooxygenase COX-1 and COX-2. Non-steroidal anti-inflammatory drugs provide important analgesic and anti-inflammatory benefits to millions of patients, but are associated with a number of serious adverse events. These include gastrointestinal toxicity, renal impairment, cardiovascular and thromboembolic complications. The mechanism underlying the serious complications associated with conventional NSAIDs and selective cyclooxygenase COX-2 inhibitors treatment is more complicated than simple imbalance between COX-1 and COX-2 inhibition and still is not clear.  A recent opinions on benefit-risk balance associated with NSAIDs treatment are presented in this report",
author="Lisowska, Barbara
and Rell-Bakalarska, Maria
and Rutkowska-Sak, Lidia",
pages="106--111",
url="https://www.termedia.pl/Review-paper-The-ups-and-downs-of-non-steroidal-anti-inflammatory-drugs,18,5914,1,1.html"
}